Research Associate

Research Associate

The Trost Lab within the Division of Molecular & Cellular Function wish to appoint a laboratory-based Research Associate to characterise bacterial phagosomes in macrophages by state-of-the-art proteomics techniques using our recent flow-cytometry based isolation approach. This position is funded for 24 months with a start date between September-December 2026.

You will be responsible for:

• Isolation of primary murine macrophages and bone marrow-derived macrophages from mice.
• Infection of macrophages with Salmonella enterica spp. Typhimurium.
• Isolation of Salmonella vacuoles/phagosomes by flow cytometry.
• Sample preparation for proteomics and collaboration with our lab’s proteomics experts.
• Utilisation of our data analysis pipelines in R.

About You

We seek a talented and enthusiastic post-doctoral scientist with a background in infection biology or either microbiology, molecular immunology, biochemistry, or cell biology. You should demonstrate:

Essential Criteria

• Have, or be about to obtain, a relevant PhD (or equivalent)
• Extensive hands-on experience with infection of mammalian cells with bacterial pathogens.
• Excellent technical skills in core lab techniques and benchwork.
• Proven ability to use initiative to efficiently plan, optimise and progress project and communicate findings.
• At least one first author publication in an internationally recognized journal (or on repository).

Desirable Criteria

• Experience with Salmonella and the ability to make mutants.
• Experience with flow cytometry.
• Experience with macrophages.
• Proficient in handling and analysing large omics datasets using R.

Our benefits include:
Generous employer contribution pension
29 days annual leave plus bank holidays, along with Christmas closure
Ride to work and EV car scheme available

For more information, please see University of Manchester Benefits. You can also find information on our Flexible and Hybrid working here.

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Enquiries about the role, shortlisting and interviews

Name: Matthias Trost

Email Address: matthias.trost@manchester.ac.uk

General enquiries and administrative support

recruitmentservices.people@manchester.ac.uk

Technical and job portal support

https://jobseekersupport.jobtrain.co.uk/support/home

Applications close at midnight on the closing date.

Further particulars (with person specification) linked below.